2024

Intergenic risk variant rs56258221 skews the fate of naive CD4+ T cells via miR4464-BACH2 interplay in primary sclerosing cholangitis
Poch T, Bahn J, Casar C, Krause J, Evangelakos I, Gilladi H, Kunzmann L, Laschtowitz A, Iuso N, Schäfer A, Liebig L, Steinmann S, Sebode M, Folseraas T, Engesæter L, Karlsen T, Franke A, Metabolic Sciences, Max Delbrück Centre for Molecular Medicine in the Helmholtz Association C, Schlein C, Galun E, Huber S, Lohse A, Gagliani N, Schwinge D, Schramm C
CELL REP MED. 2024;5(7):101620.

Next-generation phenotyping integrated in a national framework for patients with ultrarare disorders improves genetic diagnostics and yields new molecular findings
Schmidt A, Danyel M, Grundmann K, Brunet T, Klinkhammer H, Hsieh T, Engels H, Peters S, Knaus A, Moosa S, Averdunk L, Boschann F, Sczakiel H, Schwartzmann S, Mensah M, Pantel J, Holtgrewe M, Bösch A, Weiß C, Weinhold N, Suter A, Stoltenburg C, Neugebauer J, Kallinich T, Kaindl A, Holzhauer S, Bührer C, Bufler P, Kornak U, Ott C, Schülke M, Nguyen H, Hoffjan S, Grasemann C, Rothoeft T, Brinkmann F, Matar N, Sivalingam S, Perne C, Mangold E, Kreiss M, Cremer K, Betz R, Mücke M, Grigull L, Klockgether T, Spier I, Heimbach A, Bender T, Brand F, Stieber C, Morawiec A, Karakostas P, Schäfer V, Bernsen S, Weydt P, Castro-Gomez S, Aziz A, Grobe-Einsler M, Kimmich O, Kobeleva X, Önder D, Lesmann H, Kumar S, Tacik P, Basin M, Incardona P, Lee-Kirsch M, Berner R, Schuetz C, Körholz J, Kretschmer T, Di Donato N, Schröck E, Heinen A, Reuner U, Hanßke A, Kaiser F, Manka E, Munteanu M, Kuechler A, Cordula K, Hirtz R, Schlapakow E, Schlein C, Lisfeld J, Kubisch C, Herget T, Hempel M, Weiler-Normann C, Ullrich K, Schramm C, Rudolph C, Rillig F, Groffmann M, Muntau A, Tibelius A, Schwaibold E, Schaaf C, Zawada M, Kaufmann L, Hinderhofer K, Okun P, Kotzaeridou U, Hoffmann G, Choukair D, Bettendorf M, Spielmann M, Ripke A, Pauly M, Münchau A, Lohmann K, Hüning I, Hanker B, Bäumer T, Herzog R, Hellenbroich Y, Westphal D, Strom T, Kovacs R, Riedhammer K, Mayerhanser K, Graf E, Brugger M, Hoefele J, Oexle K, Mirza-Schreiber N, Berutti R, Schatz U, Krenn M, Makowski C, Weigand H, Schröder S, Rohlfs M, Vill K, Hauck F, Borggraefe I, Müller-Felber W, Kurth I, Elbracht M, Knopp C, Begemann M, Kraft F, Lemke J, Hentschel J, Platzer K, Strehlow V, Abou Jamra R, Kehrer M, Demidov G, Beck-Wödl S, Graessner H, Sturm M, Zeltner L, Schöls L, Magg J, Bevot A, Kehrer C, Kaiser N, Turro E, Horn D, Grüters-Kieslich A, Klein C, Mundlos S, Nöthen M, Riess O, Meitinger T, Krude H, Krawitz P, Haack T, Ehmke N, Wagner M
NAT GENET. 2024;56(8):1644-1653.

Fatty acid synthesis suppresses dietary polyunsaturated fatty acid use
Worthmann A, Ridder J, Piel S, Evangelakos I, Musfeldt M, Voß H, O'Farrell M, Fischer A, Adak S, Sundd M, Siffeti H, Haumann F, Kloth K, Bierhals T, Heine M, Pertzborn P, Pauly M, Scholz J, Kundu S, Fuh M, Neu A, Tödter K, Hempel M, Knippschild U, Semenkovich C, Schlüter H, Heeren J, Scheja L, Kubisch C, Schlein C
NAT COMMUN. 2024;15(1):45.

2022

Cold-Induced Lipoprotein Clearance in Cyp7b1-Deficient Mice
Evangelakos I, Kuhl A, Baguhl M, Schlein C, John C, Rohde J, Heine M, Worthmann A
FRONT CELL DEV BIOL. 2022;10(10):836741.

Apoptotic brown adipocytes enhance energy expenditure via extracellular inosine
Niemann B, Haufs-Brusberg S, Puetz L, feickert m, Jaeckstein M, Hoffmann A, Zurkovic J, Heine M, Trautmann E, Müller C, Tönies A, Schlein C, Jafari A, Eltzsching H, Gnad T, Blüher M, Krahmer N, Kovacs P, Heeren J, Pfeifer A
NATURE. 2022;609(7926):361–368.

Clinical and pathological characteristics of familial melanoma with germline TERT promoter variants
Zaremba A, Meier F, Schlein C, Jansen P, Lodde G, Song M, Kretz J, Möller I, Stadtler N, Livingstone E, Zimmer L, Hadaschik E, Sucker A, Schadendorf D, Griewank K
PIGM CELL MELANOMA R. 2022;35(6):573-586.

2021

Lysosomal lipoprotein processing in endothelial cells stimulates adipose tissue thermogenic adaptation
Fischer A, Jaeckstein M, Gottschling K, Heine M, Sass F, Mangels N, Schlein C, Worthmann A, Bruns O, Yuan Y, Zhu H, Chen O, Ittrich H, Nilsson S, Stefanicka P, Ukropec J, Balaz M, Dong H, Sun W, Reimer R, Scheja L, Heeren J
CELL METAB. 2021;33(3):547-564.e7.

TFEB-deficiency attenuates mitochondrial degradation upon brown adipose tissue whitening at thermoneutrality
Sass F, Schlein C, Jaeckstein M, Pertzborn P, Schweizer M, Schinke T, Ballabio A, Scheja L, Heeren J, Fischer A
MOL METAB. 2021;47:101173.

Endogenous Fatty Acid Synthesis Drives Brown Adipose Tissue Involution
Schlein C, Fischer A, Sass F, Worthmann A, Tödter K, Jaeckstein M, Behrens J, Lynes M, Kiebish M, Narain N, Bussberg V, Jespersen N, Nielsen S, Scheele C, Schweizer M, Braren I, Bartelt A, Tseng Y, Heeren J, Scheja L
CELL REP. 2021;34(2):108624.

2020

Brown adipose tissue lipoprotein and glucose disposal is not determined by thermogenesis in uncoupling protein 1-deficient mice
Fischer A, Behrens J, Sass F, Schlein C, Heine M, Pertzborn P, Scheja L, Heeren J
J LIPID RES. 2020;61(11):1377-1389.

Thermoneutrality-Induced Macrophage Accumulation in Brown Adipose Tissue Does Not Impair the Tissue's Competence for Cold-Induced Thermogenic Recruitment
Fischer A, de Jong J, Sass F, Schlein C, Heeren J, Petrovic N
FRONT ENDOCRINOL. 2020;11:568682.

2019

PID1 regulates insulin-dependent glucose uptake by controlling intracellular sorting of GLUT4-storage vesicles
Fischer A, Albers K, Schlein C, Sass F, Krott L, Schmale H, Gordts P, Scheja L, Heeren J
BBA-MOL BASIS DIS. 2019;1865(6):1592-1603.

Intact innervation is essential for diet-induced recruitment of brown adipose tissue
Fischer A, Schlein C, Cannon B, Heeren J, Nedergaard J
AM J PHYSIOL-ENDOC M. 2019;316(3):E487-E503.

Effects of Pharmacological Thermogenic Adipocyte Activation on Metabolism and Atherosclerotic Plaque Regression
Worthmann A, Schlein C, Berbée J, Rensen P, Heeren J, Bartelt A
NUTRIENTS. 2019;11(2):.

2018

Brown adipose tissue thermogenic adaptation requires Nrf1-mediated proteasomal activity
Bartelt A, Widenmaier S, Schlein C, Johann K, Goncalves R, Eguchi K, Fischer A, Parlakgül G, Snyder N, Nguyen T, Bruns O, Franke D, Bawendi M, Lynes M, Leiria L, Tseng Y, Inouye K, Arruda A, Hotamisligil G
NAT MED. 2018;24(3):292-303.

Lipolysis Triggers a Systemic Insulin Response Essential for Efficient Energy Replenishment of Activated Brown Adipose Tissue in Mice
Heine M, Fischer A, Schlein C, Jung C, Straub L, Gottschling K, Mangels N, Yuan Y, Nilsson S, Liebscher G, Chen O, Schreiber R, Zechner R, Scheja L, Heeren J
CELL METAB. 2018;28(4):644-655.e4.

Course of HEV viremia and anti-HEV IgM/IgG response in asymptomatic blood donors
Kraef C, Schlein C, Hiller J, Westhölter D, Denzer U, Horvatits T, Peine S, Lohse A, Lütgehetmann M, Polywka S, Pischke S
J CLIN VIROL. 2018;105:26-30.

FoxO transcription factors are required for hepatic HDL-cholesterol clearance
Lee S, Heine M, Schlein C, Ramakrishnan R, Liu J, Belnavis G, Haimi I, Fischer A, Ginsberg H, Heeren J, Rinninger F, Haeusler R
J CLIN INVEST. 2018;128(4):1615-1626.

2017

Thermogenic adipocytes promote HDL turnover and reverse cholesterol transport
Bartelt A, John C, Schaltenberg N, Berbée J, Worthmann A, Cherradi M, Schlein C, Piepenburg J, Boon M, Rinninger F, Heine M, Toedter K, Niemeier A, Nilsson S, Fischer M, Wijers S, van Marken Lichtenbelt W, Scheja L, Rensen P, Heeren J
NAT COMMUN. 2017;8:Art. 15010.

Cold-induced conversion of cholesterol to bile acids in mice shapes the gut microbiome and promotes adaptive thermogenesis
Worthmann A, John C, Rühlemann M, Baguhl M, Heinsen F, Schaltenberg N, Heine M, Schlein C, Evangelakos I, Mineo C, Fischer M, Dandri M, Kremoser C, Scheja L, Franke A, Shaul P, Heeren J
NAT MED. 2017;23(7):839-849.

2016

Exosomal microRNA miR-92a concentration in serum reflects human brown fat activity
Chen Y, Buyel J, Hanssen M, Siegel F, Pan R, Naumann J, Schell M, van der Lans A, Schlein C, Froehlich H, Heeren J, Virtanen K, van Marken Lichtenbelt W, Pfeifer A
NAT COMMUN. 2016;7:11420.

Implications of thermogenic adipose tissues for metabolic health
Schlein C, Heeren J
BEST PRACT RES CL EN. 2016;30(4):487-496.

FGF21 Lowers Plasma Triglycerides by Accelerating Lipoprotein Catabolism in White and Brown Adipose Tissues
Schlein C, Talukdar S, Heine M, Fischer A, Krott L, Nilsson S, Brenner M, Heeren J, Scheja L
CELL METAB. 2016;23(3):441-53.

2015

Brown fat activation reduces hypercholesterolaemia and protects from atherosclerosis development
Berbée J, Boon M, Khedoe P, Bartelt A, Schlein C, Worthmann A, Kooijman S, Hoeke G, Mol I, John C, Jung C, Vazirpanah N, Brouwers L, Gordts P, Esko J, Hiemstra P, Havekes L, Scheja L, Heeren J, Rensen P
NAT COMMUN. 2015;6:6356.

Genetic Dissection of Tissue-Specific Apolipoprotein E Function for Hypercholesterolemia and Diet-Induced Obesity
Wagner T, Bartelt A, Schlein C, Heeren J
PLOS ONE. 2015;10(12):.

2014

Homozygosity for a partial deletion of apoprotein A-V signal peptide results in intracellular missorting of the protein and chylomicronemia in a breast-fed infant
Albers K, Schlein C, Wenner K, Lohse P, Bartelt A, Heeren J, Santer R, Merkel M
ATHEROSCLEROSIS. 2014;233(1):97-103.

Letzte Aktualisierung aus dem FIS: 01.12.2024 - 23:36 Uhr