Multicenter benchmarking of short and long read wet lab protocols for clinical viral metagenomics
Lopez-Labrador F, Huber M, Sidorov I, Brown J, Cuypers L, Laenen L, Vanmechelen B, Maes P, Fischer N, Pichler I, Storey N, Atkinson L, Schmutz S, Kufner V, van Boheemen S, Mulders C, Grundhoff A, Blümke P, Robitaille A, Cinek O, Hubáčková K, Mourik K, Boers S, Stauber L, Salmona M, Cappy P, Ramette A, Franze' A, LeGoff J, Claas E, Rodriguez C, de Vries J
J CLIN VIROL. 2024;173:105695.

Merkel cell polyomavirus small tumor antigen contributes to immune evasion by interfering with type I interferon signaling
Ohnezeit D, Huang J, Westerkamp U, Brinschwitz V, Schmidt C, Günther T, Czech-Sioli M, Weißelberg S, Schlemeyer T, Nakel J, Mai J, Schreiner S, Schneider C, Friedel C, Schwanke H, Brinkmann M, Grundhoff A, Fischer N
PLOS PATHOG. 2024;20(8):.

Revisiting diagnostics: Microbial cell free DNA-sequencing: addressing unmet challenges in implant-related cardiovascular Infections
Olearo F, Christner M, Lütgehetmann M, Aepfelbacher M, Fischer N, Rohde H
CLIN MICROBIOL INFEC. 2024 [Epub ahead of print].

Drug repurposing screen identifies lonafarnib as respiratory syncytial virus fusion protein inhibitor
Sake S, Zhang X, Rajak M, Urbanek-Quaing M, Carpentier A, Gunesch A, Grethe C, Matthaei A, Rückert J, Galloux M, Larcher T, Le Goffic R, Hontonnou F, Chatterjee A, Johnson K, Morwood K, Rox K, Elgaher W, Huang J, Wetzke M, Hansen G, Fischer N, Eléouët J, Rameix-Welti M, Hirsch A, Herold E, Empting M, Lauber C, Krey T, Haid S, Pietschmann T
NAT COMMUN. 2024;15(1):1173.

Analytical and clinical validation of a novel, laboratory-developed, modular multiplex-PCR panel for fully automated high-throughput detection of 16 respiratory viruses
Tang H, Nörz D, Grunwald M, Giersch K, Pfefferle S, Fischer N, Aepfelbacher M, Rohde H, Lütgehetmann M
J CLIN VIROL. 2024;173:105693.

Cancer-Associated Fibroblasts Exert Proangiogenic Activity in Merkel Cell Carcinoma
Albertini S, Martuscelli L, Borgogna C, Virdi S, Indenbirken D, Lo Cigno I, Griffante G, Calati F, Boldorini R, Fischer N, Gariglio M
J INVEST DERMATOL. 2023;143(6):965-976.e15.

Integration of Sequencing and Epidemiologic Data for Surveillance of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infections in a Tertiary-Care Hospital
Czech-Sioli M, Günther T, Robitaille A, Roggenkamp H, Büttner H, Indenbirken D, Christner M, Lütgehetmann M, Knobloch J, Aepfelbacher M, Grundhoff A, Fischer N
CLIN INFECT DIS. 2023;76(3):e263-e273.

Target capture sequencing reveals a monoclonal outbreak of respiratory syncytial virus B infections among adult hematologic patients
Baier C, Huang J, Reumann K, Indenbirken D, Thol F, Koenecke C, Ebadi E, Heim A, Bange F, Haid S, Pietschmann T, Fischer N
ANTIMICROB RESIST IN. 2022;11(1):88.

Expanded Diversity and Host Range of Bovine Hepacivirus-Genomic and Serological Evidence in Domestic and Wild Ruminant Species
Breitfeld J, Fischer N, Tsachev I, Marutsov P, Baymakova M, Plhal R, Keuling O, Becher P, Baechlein C
VIRUSES-BASEL. 2022;14(7):.

High and Sustained Ex Vivo Frequency but Altered Phenotype of SARS-CoV-2-Specific CD4+ T-Cells in an Anti-CD20-Treated Patient with Prolonged COVID-19
Cords L, Knapp M, Woost R, Schulte S, Kummer S, Ackermann C, Beisel C, Peine S, Johansson A, Kwok W, Günther T, Fischer N, Wittner M, Addo M, Huber S, Schulze Zur Wiesch J
VIRUSES-BASEL. 2022;14(6):.

Dying of VOC-202012/01 - multimodal investigations in a death case of the SARS-CoV-2 variant
Heinrich F, Romich C, Zimmermann T, Kniep I, Fitzek A, Steurer S, Glatzel M, Nörz D, Günther T, Czech-Sioli M, Fischer N, Grundhoff A, Lütgehetmann M, Ondruschka B
INT J LEGAL MED. 2022;136(1):193-202.

Remdesivir-induced emergence of SARS-CoV2 variants in patients with prolonged infection
Heyer A, Günther T, Robitaille A, Lütgehetmann M, Addo M, Jarczak D, Kluge S, Aepfelbacher M, Schulze Zur Wiesch J, Fischer N, Grundhoff A
CELL REP MED. 2022;3(9):.

Mechanisms of CD8+ T cell failure in chronic hepatitis E virus infection
Kemming J, Gundlach S, Panning M, Huzly D, Huang J, Lütgehetmann M, Fischer N, Neumann-Haefelin C
J HEPATOL. 2022;77(4):978-990.

Comparing susceptibility and contagiousness in concurrent outbreaks with a non-VOC and the VOC SARS-CoV-2 variant B.1.1.7 in daycare centers in Hamburg, Germany
Nakel J, Robitaille A, Günther T, Rosenau L, Czech-Sioli M, Plenge-Bönig A, Bühler S, Wille A, Jakubowski E, Pruskil S, Wahlen M, Indenbirken D, Nörz D, Lütgehetmann M, Aepfelbacher M, Grundhoff A, Grolle B, Fischer N
INT J HYG ENVIR HEAL. 2022;240:.

Clinical characteristics and comparison of longitudinal qPCR results from different specimen types in a cohort of ambulatory and hospitalized patients infected with monkeypox virus
Nörz D, Brehm T, Tang H, Grewe I, Hermanussen L, Matthews H, Pestel J, Degen O, Günther T, Grundhoff A, Fischer N, Addo M, Jordan S, Hertling S, Unger S, Schäfer G, Schewe K, Hoffmann C, Aepfelbacher M, Pfefferle S, Schulze Zur Wiesch J, Schmiedel S, Lütgehetmann M
J CLIN VIROL. 2022;155:.

Clinical Evaluation of a Fully-Automated High-Throughput Multiplex Screening-Assay to Detect and Differentiate the SARS-CoV-2 B.1.1.529 (Omicron) and B.1.617.2 (Delta) Lineage Variants
Nörz D, Grunwald M, Tang H, Weinschenk C, Günther T, Robitaille A, Giersch K, Fischer N, Grundhoff A, Aepfelbacher M, Pfefferle S, Lütgehetmann M
VIRUSES-BASEL. 2022;14(3):.

Rapid Adaptation of Established High-Throughput Molecular Testing Infrastructure for Monkeypox Virus Detection
Nörz D, Tang H, Emmerich P, Giersch K, Fischer N, Schmiedel S, Addo M, Aepfelbacher M, Pfefferle S, Lütgehetmann M
EMERG INFECT DIS. 2022;28(9):1765-1769.

Multi-organ assessment in mainly non-hospitalized individuals after SARS-CoV-2 infection: The Hamburg City Health Study COVID programme
Petersen E, Goßling A, Adam G, Aepfelbacher M, Behrendt C, Cavus E, Cheng B, Fischer N, Gallinat J, Kühn S, Gerloff C, Koch-Gromus U, Härter M, Hanning U, Huber T, Kluge S, Knobloch J, Kuta P, Schmidt-Lauber C, Lütgehetmann M, Magnussen C, Mayer C, Muellerleile K, Münch J, Nägele F, Petersen M, Renné T, Riedl K, Rimmele D, Schäfer I, Schulz H, Tahir E, Waschki B, Wenzel J, Zeller T, Ziegler A, Thomalla G, Twerenbold R, Blankenberg S
EUR HEART J. 2022;43(11):1124-1137.

Respiratory Syncytial Virus Two-Step Infection Screen Reveals Inhibitors of Early and Late Life Cycle Stages
Sake S, Kosch C, Blockus S, Haid S, Gunesch A, Zhang X, Friesland M, Trummer S, Grethe C, Kühnel A, Rückert J, Duprex W, Huang J, Rameix-Welti M, Empting M, Fischer N, Hirsch A, Schulz T, Pietschmann T
ANTIMICROB AGENTS CH. 2022;66(12):.

Pregnancy-induced maternal microchimerism shapes neurodevelopment and behavior in mice
Schepanski S, Chini M, Sternemann V, Urbschat C, Thiele K, Sun T, Zhao Y, Poburski M, Woestemeier A, Thieme M, Zazara D, Alawi M, Fischer N, Heeren J, Vladimirov N, Woehler A, Puelles V, Bonn S, Gagliani N, Hanganu-Opatz I, Arck P
NAT COMMUN. 2022;13(1):.

Merkel cell carcinoma and immune evasion: Merkel cell polyomavirus small T-antigen induced surface changes can be reverted by therapeutic intervention
Schlemeyer T, Ohnezeit D, Virdi S, Körner C, Weißelberg S, Starzonek S, Schumacher U, Grundhoff A, Indenbirken D, Albertini S, Fischer N
J INVEST DERMATOL. 2022;142(11):3071-3081.e13.

In the Search of Marine Pestiviruses:First Case of Phocoena Pestivirus in a Belt Sea Harbour Porpoise
Stokholm I, Fischer N, Baechlein C, Postel A, Galatius A, Kyhn L, Thøstesen C, Persson S, Siebert U, Olsen M, Becher P
VIRUSES-BASEL. 2022;14(1):.

First report from the German COVID-19 autopsy registry
von Stillfried S, Bülow R, Röhrig R, Boor P
LANCET REG HEALTH-EU. 2022;15:.

Intracranial hemorrhage in COVID-19 patients during extracorporeal membrane oxygenation for acute respiratory failure: a nationwide register study report
von Stillfried S, Bülow R, Röhrig R, Meybohm P, Boor P
CRIT CARE. 2022;26(1):.

Update zur kooperativen autopsiebasierten Forschung in der deutschen Pathologie, Neuropathologie und Gerichtsmedizin
von Stillfried S, Freeborn B, Windeck S, Boor P
PATHOLOGIE. 2022;43(Suppl 1):101-105.

Molecular consequences of SARS-CoV-2 liver tropism
Wanner N, Andrieux G, Badia-I-Mompel P, Edler C, Pfefferle S, Lindenmeyer M, Schmidt-Lauber C, Czogalla J, Wong M, Okabayashi Y, Braun F, Lütgehetmann M, Meister E, Lu S, Noriega M, Günther T, Grundhoff A, Fischer N, Bräuninger H, Lindner D, Westermann D, Haas F, Roedl K, Kluge S, Addo M, Huber S, Lohse A, Reiser J, Ondruschka B, Sperhake J, Saez-Rodriguez J, Boerries M, Hayek S, Aepfelbacher M, Scaturro P, Puelles V, Huber T
NAT METAB. 2022;4(3):310-319.

Yersinia remodels epigenetic histone modifications in human macrophages
Bekere I, Huang J, Schnapp M, Rudolph M, Berneking L, Ruckdeschel K, Grundhoff A, Günther T, Fischer N, Aepfelbacher M
PLOS PATHOG. 2021;17(11):.

SARS-CoV-2 Reinfection in a Healthcare Worker Despite the Presence of Detectable Neutralizing Antibodies
Brehm T, Pfefferle S, von Possel R, Kobbe R, Nörz D, Schmiedel S, Grundhoff A, Olearo F, Emmerich P, Robitaille A, Günther T, Braun P, Andersen G, Knobloch J, Addo M, Lohse A, Aepfelbacher M, Fischer N, Schulze Zur Wiesch J, Lütgehetmann M
VIRUSES-BASEL. 2021;13(4):.

Recommendations for the introduction of metagenomic next-generation sequencing in clinical virology, part II:bioinformatic analysis and reporting
de Vries J, Brown J, Couto N, Beer M, Le Mercier P, Sidorov I, Papa A, Fischer N, Oude Munnink B, Rodriquez C, Zaheri M, Sayiner A, Hönemann M, Cataluna A, Carbo E, Bachofen C, Kubacki J, Schmitz D, Tsioka K, Matamoros S, Höper D, Hernandez M, Puchhammer-Stöckl E, Lebrand A, Huber M, Simmonds P, Claas E, López-Labrador F
J CLIN VIROL. 2021;138:.

Benchmark of thirteen bioinformatic pipelines for metagenomic virus diagnostics using datasets from clinical samples
de Vries J, Brown J, Fischer N, Sidorov I, Morfopoulou S, Huang J, Munnink B, Sayiner A, Bulgurcu A, Rodriguez C, Gricourt G, Keyaerts E, Beller L, Bachofen C, Kubacki J, Samuel C, Florian L, Dennis S, Beer M, Hoeper D, Huber M, Kufner V, Zaheri M, Lebrand A, Papa A, van Boheemen S, Kroes A, Breuer J, Lopez-Labrador F, Claas E
J CLIN VIROL. 2021;141:.

Real time, in-line optical mapping of single molecules of DNA
Esmek F, Erichlandwehr T, Mors D, Czech-Sioli M, Therre M, Günther T, Grundhoff A, Fischer N, Fernandez-Cuesta I
Biosensors and Bioelectronics: X. 2021;9:.

Clinical evaluation of a laboratory-developed quantitative BK virus-PCR assay using the cobas® omni Utility Channel
Fritzsche A, Berneking L, Nörz D, Reucher S, Fischer N, Roggenkamp H, Aepfelbacher M, Rohde H, Pfefferle S, Lütgehetmann M
J VIROL METHODS. 2021;290:114093.

Strong Replication Interference Between Hepatitis Delta Viruses in Human Liver Chimeric Mice
Giersch K, Hermanussen L, Volz T, Volmari A, Allweiss L, Sureau C, Casey J, Huang J, Fischer N, Lütgehetmann M, Dandri M
FRONT MICROBIOL. 2021;12:671466.

A resampling strategy for studying robustness in virus detection pipelines
Kohls M, Saremi B, Muchsin I, Fischer N, Becher P, Jung K
COMPUT BIOL CHEM. 2021;94:.

Upregulation of HLA-F expression by BK polyomavirus infection induces immune recognition by KIR3DS1-positive natural killer cells
Koyro T, Kraus E, Lunemann S, Hölzemer A, Wulf S, Jung J, Fittje P, Henseling F, Körner C, Huber T, Grundhoff A, Wiech T, Panzer U, Fischer N, Altfeld M
KIDNEY INT. 2021;99(5):1140-1148.

Recommendations for the introduction of metagenomic high-throughput sequencing in clinical virology, part I:Wet lab procedure
López-Labrador F, Brown J, Fischer N, Harvala H, Van Boheemen S, Cinek O, Sayiner A, Madsen T, Auvinen E, Kufner V, Huber M, Rodriguez C, Jonges M, Hönemann M, Susi P, Sousa H, Klapper P, Pérez-Cataluňa A, Hernandez M, Molenkamp R, der Hoek L, Schuurman R, Couto N, Leuzinger K, Simmonds P, Beer M, Höper D, Kamminga S, Feltkamp M, Rodríguez-Díaz J, Keyaerts E, Nielsen X, Puchhammer-Stöckl E, Kroes A, Buesa J, Breuer J, Claas E, de Vries J
J CLIN VIROL. 2021;134:.

Evaluation of a fully automated high-throughput SARS-CoV-2 multiplex qPCR assay with built-in screening functionality for del-HV69/70- and N501Y variants such as B.1.1.7
Nörz D, Grunwald M, Olearo F, Fischer N, Aepfelbacher M, Pfefferle S, Lütgehetmann M
J CLIN VIROL. 2021;141:.

Rapid Automated Screening for SARS-CoV-2 B.1.617 Lineage Variants (Delta/Kappa) through a Versatile Toolset of qPCR-Based SNP Detection
Nörz D, Grunwald M, Tang H, Olearo F, Günther T, Robitaille A, Fischer N, Grundhoff A, Aepfelbacher M, Pfefferle S, Lütgehetmann M
DIAGNOSTICS. 2021;11(10):.

Modifying a Diagnostic SARS-CoV-2 Spike PCR to Turn a Del69/70 Dropout into a Discriminatory On-Target Assay
Nörz D, Pfefferle S, Grunwald M, Fischer N, Aepfelbacher M, Lütgehetmann M
J MOL DIAGN. 2021;23(6):777-778.

An inter‑laboratory study to investigate the impact of the bioinformatics component on microbiome analysis using mock communities
O’Sullivan D, Doyle R, Temisak S, Redshaw N, Whale A, Logan G, Huang J, Fischer N, Amos G, Preston M, Marchesi J, Wagner J, Parkhill J, Motro Y, Denise H, Finn R, Kay G, O'Grady J, Ransom-Jones E, Wu H, Laing E, Benavente E, Phelan J, Clark T, Moran-Gilad J, Huggett J
SCI REP-UK. 2021;11(1):10590.

SARS Coronavirus-2 variant tracing within the first Coronavirus Disease 19 clusters in northern Germany
Pfefferle S, Günther T, Kobbe R, Czech-Sioli M, Nörz D, Santer R, Oh J, Kluge S, Oestereich L, Peldschus K, Indenbirken D, Huang J, Grundhoff A, Aepfelbacher M, Knobloch J, Lütgehetmann M, Fischer N
CLIN MICROBIOL INFEC. 2021;27(1):130.e5-130.e8.

Vertically transferred maternal immune cells promote neonatal immunity against early life infections
Stelzer I, Urbschat C, Schepanski S, Thiele K, Triviai I, Wieczorek A, Alawi M, Ohnezeit D, Kottlau J, Huang J, Fischer N, Mittrücker H, Solano M, Fehse B, Diemert A, Stahl F, Arck P
NAT COMMUN. 2021;12(1):4706.

Merkel Cell Polyomavirus Encodes Circular RNAs (circRNAs) Enabling a Dynamic circRNA/microRNA/mRNA Regulatory Network
Abere B, Zhou H, Li J, Cao S, Toptan T, Grundhoff A, Fischer N, Moore P, Chang Y
MBIO. 2020;11(6):.

High-resolution analysis of Merkel Cell Polyomavirus in Merkel Cell Carcinoma reveals distinct integration patterns and suggests NHEJ and MMBIR as underlying mechanisms
Czech-Sioli M, Günther T, Therre M, Spohn M, Indenbirken D, Theiss J, Riethdorf S, Qi M, Alawi M, Wülbeck C, Fernandez-Cuesta I, Esmek F, Becker J, Grundhoff A, Fischer N
PLOS PATHOG. 2020;16(8):.

The Ubiquitin specific Protease Usp7, a novel Merkel cell polyomavirus Large T-Antigen interaction partner, modulates viral DNA replication
Czech-Sioli M, Siebels S, Radau S, Zahedi R, Schmidt C, Dobner T, Grundhoff A, Fischer N
J VIROL. 2020;94(5):.

Infection-induced epigenetic changes and their impact on the pathogenesis of diseases
Fischer N
SEMIN IMMUNOPATHOL. 2020;42(2):127-130.

SARS-CoV-2 outbreak investigation in a German meat processing plant
Günther T, Czech-Sioli M, Indenbirken D, Robitaille A, Tenhaken P, Exner M, Ottinger M, Fischer N, Grundhoff A, Brinkmann M
EMBO MOL MED. 2020;12(12):e13296.

Major central nervous system complications after allogeneic stem cell transplantation: a large retrospective study on 888 consecutive adult patients
Mannina D, Berneking L, Both A, Timm W, Urbanowicz T, Wolschke C, Ayuk F, Fischer N, Fiehler J, Grzyska U, Rösner S, Choe C, Kröger N, Christopeit M
EUR J HAEMATOL. 2020;105(6):722-730.

Clinical evaluation of a SARS-CoV-2 RT-PCR assay on a fully automated system for rapid on-demand testing in the hospital setting
Nörz D, Fischer N, Schultze A, Kluge S, Mayer-Runge U, Aepfelbacher M, Pfefferle S, Lütgehetmann M
J CLIN VIROL. 2020;128:104390.

Pushing beyond specifications:Evaluation of linearity and clinical performance of the cobas 6800/8800 SARS-CoV-2 RT-PCR assay for reliable quantification in blood and other materials outside recommendations
Nörz D, Frontzek A, Eigner U, Oestereich L, Wichmann D, Kluge S, Fischer N, Aepfelbacher M, Pfefferle S, Lütgehetmann M
J CLIN VIROL. 2020;132:104650.

Complete Genome Sequence of a SARS-CoV-2 Strain Isolated in Northern Germany
Pfefferle S, Huang J, Nörz D, Indenbirken D, Lütgehetmann M, Oestereich L, Günther T, Grundhoff A, Aepfelbacher M, Fischer N
MICROBIOL RESOUR ANN. 2020;9(23):.

PVAmpliconFinder: a workflow for the identification of human papillomaviruses from high-throughput amplicon sequencing
Robitaille A, Brancaccio R, Dutta S, Rollison D, Leja M, Fischer N, Grundhoff A, Gheit T, Tommasino M, Olivier M
BMC BIOINFORMATICS. 2020;21(1):233.

Merkel Cell Polyomavirus DNA Replication Induces Senescence in Human Dermal Fibroblasts in a Kap1/Trim28-Dependent Manner
Siebels S, Czech-Sioli M, Spohn M, Schmidt C, Theiss J, Indenbirken D, Günther T, Grundhoff A, Fischer N
MBIO. 2020;11(2):.

DAMIAN an open source bioinformatics tool for fast, systematic and cohort based analysis of microorganisms in diagnostic samples
Alawi M, Burkhardt L, Indenbirken D, Reumann K, Christopeit M, Kröger N, Lütgehetmann M, Aepfelbacher M, Fischer N, Grundhoff A
SCI REP-UK. 2019;9(1):16841.

Further characterization of bovine hepacivirus: Antibody response, course of infection, and host tropism
Baechlein C, Baron A, Meyer D, Gorriz-Martin L, Pfankuche V, Baumgärtner W, Polywka S, Peine S, Fischer N, Rehage J, Becher P
TRANSBOUND EMERG DIS. 2019;66(1):195-206.

Piscine Orthoreovirus 3 Is Not the Causative Pathogen of Proliferative Darkening Syndrome (PDS) of Brown Trout ()
Fux R, Arndt D, Langenmayer M, Schwaiger J, Ferling H, Fischer N, Indenbirken D, Grundhoff A, Dölken L, Adamek M, Steinhagen D, Sutter G
VIRUSES-BASEL. 2019;11(2):.

Changes in the composition of the upper respiratory tract microbial community in granulomatosis with polyangiitis
Lamprecht P, Fischer N, Huang J, Burkhardt L, Lütgehetmann M, Arndt F, Rolfs I, Kerstein A, Iking-Konert C, Laudien M
J AUTOIMMUN. 2019;97:29-39.

Detection and Characterization of Circulating Tumor Cells in Patients with Merkel Cell Carcinoma
Riethdorf S, Hildebrandt L, Heinzerling L, Heitzer E, Fischer N, Bergmann S, Mauermann O, Waldispühl-Geigl J, Coith C, Schön G, Peine S, Schuler G, Speicher M, Moll I, Pantel K
CLIN CHEM. 2019;65(3):462-472.

Identification of a novel clade of group A rotaviruses in fatally diseased domestic pigeons in Europe
Rubbenstroth D, Peus E, Schramm E, Kottmann D, Bartels H, McCowan C, Schulze C, Akimkin V, Fischer N, Wylezich C, Hlinak A, Spadinger A, Großmann E, Petersen H, Grundhoff A, Rautenschlein S, Teske L
TRANSBOUND EMERG DIS. 2019;66(1):552-561.

Chronic equine hepacivirus infection in an adult gelding with severe hepatopathy
Tegtmeyer B, Echelmeyer J, Pfankuche V, Puff C, Todt D, Fischer N, Durham A, Feige K, Baumgärtner W, Steinmann E, Cavalleri J
VET MED SCI. 2019;5(3):372-378.

Novel Human Polyomavirus Noncoding Control Regions Differ in Bidirectional Gene Expression according to Host Cell, Large T-Antigen Expression, and Clinically Occurring Rearrangements
Ajuh E, Wu Z, Kraus E, Weissbach F, Bethge T, Gosert R, Fischer N, Hirsch H
J VIROL. 2018;92(7):e02231-17.

Epidemiology, biology and therapy of Merkel cell carcinoma:conclusions from the EU project IMMOMEC
Becker J, Stang A, Hausen A, Fischer N, DeCaprio J, Tothill R, Lyngaa R, Hansen U, Ritter C, Nghiem P, Bichakjian C, Ugurel S, Schrama D
CANCER IMMUNOL IMMUN. 2018;67(3):341-351.

Generation of a novel next-generation sequencing-based method for the isolation of new human papillomavirus types
Brancaccio R, Robitaille A, Dutta S, Cuenin C, Santare D, Skenders G, Leja M, Fischer N, Giuliano A, Rollison D, Grundhoff A, Tommasino M, Gheit T
VIROLOGY. 2018;520:1-10.

Pathogenetic and Clinical Aspects of Anti-Neutrophil Cytoplasmic Autoantibody-Associated Vasculitides
Lamprecht P, Kerstein A, Klapa S, Schinke S, Karsten C, Yu X, Ehlers M, Epplen J, Holl-Ulrich K, Wiech T, Kalies K, Lange T, Laudien M, Laskay T, Gemoll T, Schumacher U, Ullrich S, Busch H, Ibrahim S, Fischer N, Hasselbacher K, Pries R, Petersen F, Weppner G, Manz R, Humrich J, Nieberding R, Riemekasten G, Müller A
FRONT IMMUNOL. 2018;9:680.

HEV-positive blood donations represent a relevant infection risk for immunosuppressed recipients
Westhölter D, Hiller J, Denzer U, Polywka S, Ayuk F, Rybczynski M, Horvatits T, Gundlach S, Blöcker J, Schulze Zur Wiesch J, Fischer N, Addo M, Peine S, Göke B, Lohse A, Lütgehetmann M, Pischke S
J HEPATOL. 2018;69(1):36-42.

Complete Genome Sequence of a Novel Human Gammapapillomavirus Isolated from Skin
Brancaccio R, Robitaille A, Dutta S, Rollison D, Fischer N, Grundhoff A, Tommasino M, Gheit T
Genome Announc. 2017;5(34):.

Novel poly-uridine insertion in the 3'UTR and E2 amino acid substitutions in a low virulent classical swine fever virus
Coronado L, Liniger M, Muñoz-González S, Postel A, Pérez L, Pérez-Simó M, Perera C, Frías-Lepoureau M, Rosell R, Grundhoff A, Indenbirken D, Alawi M, Fischer N, Becher P, Ruggli N, Ganges L
VET MICROBIOL. 2017;201:103-112.

Pregnancy-Related Immune Adaptation Promotes the Emergence of Highly Virulent H1N1 Influenza Virus Strains in Allogenically Pregnant Mice
Engels G, Hierweger A, Hoffmann J, Thieme R, Thiele S, Bertram S, Dreier C, Resa-Infante P, Jacobsen H, Thiele K, Alawi M, Indenbirken D, Grundhoff A, Siebels S, Fischer N, Stojanovska V, Muzzio D, Jensen F, Karimi K, Mittrücker H, Arck P, Gabriel G
CELL HOST MICROBE. 2017;21(3):321-333.

Recovery of the first full-length genome sequence of a parapoxvirus directly from a clinical sample
Günther T, Haas L, Alawi M, Wohlsein P, Marks J, Grundhoff A, Becher P, Fischer N
SCI REP-UK. 2017;7(1):3734.

Spontaneous lung metastasis formation of human Merkel cell carcinoma cell lines transplanted into scid mice
Knips J, Czech-Sioli M, Spohn M, Heiland M, Moll I, Grundhoff A, Schumacher U, Fischer N
INT J CANCER. 2017;141(1):160-171.

High Abundance and Genetic Variability of Atypical Porcine Pestivirus in Pigs from Europe and Asia
Postel A, Meyer D, Cagatay G, Feliziani F, De Mia G, Fischer N, Grundhoff A, Milićević V, Deng M, Chang C, Qiu H, Sun Y, Wendt M, Becher P
EMERG INFECT DIS. 2017;23(12):2104-2107.

Successful retreatment of a patient with chronic hepatitis C genotype 2k/1b virus with ombitasvir/paritaprevir/ritonavir plus dasabuvir
Todt D, Schlevogt B, Deterding K, Grundhoff A, Manns M, Wedemeyer H, Fischer N, Cornberg M, Steinmann E
J ANTIMICROB CHEMOTH. 2017;72(5):1541-1543.

Pegivirus Infection in Domestic Pigs, Germany
Baechlein C, Grundhoff A, Fischer N, Alawi M, Hoeltig D, Waldmann K, Becher P
EMERG INFECT DIS. 2016;22(7):1312-4.

Suspected encephalitis with Candida tropicalis and Fusarium detected by unbiased RNA sequencing
Christopeit M, Grundhoff A, Rohde H, Belmar-Campos C, Grzyska U, Fiehler J, Wolschke C, Kröger N, Fischer N
ANN HEMATOL. 2016;95(11):1919-1921.

Investigation of Viral and Host Chromatin by ChIP-PCR or ChIP-Seq Analysis
Günther T, Theiss J, Fischer N, Grundhoff A
Curr Protoc Microbiol. 2016;40:1E.10.1-1E.10.21.

Multicenter quality assessment of 16S ribosomal DNA-sequencing for microbiome analyses reveals high inter-center variability
Hiergeist A, Reischl U, , Gessner A
INT J MED MICROBIOL. 2016;306(5):334-42.

Autoimmune Renal Disease Is Exacerbated by S1P-Receptor-1-Dependent Intestinal Th17 Cell Migration to the Kidney
Krebs C, Paust H, Krohn S, Koyro T, Brix S, Riedel J, Bartsch P, Wiech T, Meyer-Schwesinger C, Huang J, Fischer N, Busch C, Mittrücker H, Steinhoff U, Stockinger B, Perez L, Wenzel U, Janneck M, Steinmetz O, Gagliani N, Stahl R, Huber S, Turner J, Panzer U
IMMUNITY. 2016;45(5):1078-1092.

Replication of merkel cell polyomavirus induces reorganization of promyelocytic leukemia nuclear bodies
Neumann F, Czech-Sioli M, Dobner T, Grundhoff A, Schreiner S, Fischer N
J GEN VIROL. 2016;97(11):2926-2938.

Frequent presence of hepaci and pegiviruses in commercial equine serum pools
Postel A, Cavalleri J, Pfaender S, Walter S, Steinmann E, Fischer N, Feige K, Haas L, Becher P
VET MICROBIOL. 2016;182:8-14.

Presence of atypical porcine pestivirus (APPV) genomes in newborn piglets correlates with congenital tremor
Postel A, Hansmann F, Baechlein C, Fischer N, Alawi M, Grundhoff A, Derking S, Tenhündfeld J, Pfankuche V, Herder V, Baumgärtner W, Wendt M, Becher P
SCI REP-UK. 2016;6:27735.

Tropheryma whipplei in children with diarrhoea in rural Ghana
Vinnemeier C, Klupp E, Krumkamp R, Rolling T, Fischer N, Owusu-Dabo E, Addo M, Adu-Sarkodie Y, Käsmaier J, Aepfelbacher M, Cramer J, May J, Tannich E
CLIN MICROBIOL INFEC. 2016;22(1):65.e1 - 65.e3.

Highly divergent hepaciviruses from African cattle
Corman V, Grundhoff A, Baechlein C, Fischer N, Gmyl A, Wollny R, Dei D, Ritz D, Binger T, Adankwah E, Marfo K, Annison L, Annan A, Adu-Sarkodie Y, Oppong S, Becher P, Drosten C, Drexler J
J VIROL. 2015;89(11):5876-82.

Identification of a Novel Hepacivirus in Domestic Cattle from Germany
Fischer N, Baechlein C, Grundhoff A, Alawi M, Indenbirken D, Postel A, Baron A, Offinger J, Becker K, Beineke A, Rehage J, Becher P
J VIROL. 2015;89(14):7007-15.

Evaluation of Unbiased Next-Generation Sequencing of RNA (RNA-seq) as a Diagnostic Method in Influenza Virus-Positive Respiratory Samples
Fischer N, Indenbirken D, Meyer T, Lütgehetmann M, Lellek H, Spohn M, Aepfelbacher M, Alawi M, Grundhoff A
J CLIN MICROBIOL. 2015;53(7):2238-50.

Merkel cell polyomavirus, a highly prevalent virus with tumorigenic potential
Grundhoff A, Fischer N
CURR OPIN VIROL. 2015;14:129-137.

In Vitro Replication Assay for Merkel Cell Polyomavirus (MCPyV)
Neumann F, Czech-Sioli M, Grundhoff A, Fischer N
Curr Protoc Microbiol. 2015;38:14F.2.1-14F.2.19.

Close relationship of ruminant pestiviruses and classical Swine Fever virus
Postel A, Schmeiser S, Oguzoglu T, Indenbirken D, Alawi M, Fischer N, Grundhoff A, Becher P
EMERG INFECT DIS. 2015;21(4):668-72.

A Comprehensive Analysis of Replicating Merkel Cell Polyomavirus Genomes Delineates the Viral Transcription Program and Suggests a Role for mcv-miR-M1 in Episomal Persistence
Theiss J, Günther T, Alawi M, Neumann F, Tessmer U, Fischer N, Grundhoff A
PLOS PATHOG. 2015;11(7):e1004974.

Complete Genome Sequence of Bovine Pestivirus Strain PG-2, a Second Member of the Tentative Pestivirus Species Giraffe
Becher P, Fischer N, Grundhoff A, Stalder H, Schweizer M, Postel A
Genome Announc. 2014;2(3):.

High-affinity Rb Binding, p53 Inhibition, Subcellular Localization, and Transformation by Wild-Type or Tumor-Derived Shortened Merkel Cell Polyomavirus Large T Antigens
Borchert S, Czech-Sioli M, Neumann F, Schmidt C, Wimmer P, Dobner T, Grundhoff A, Fischer N
J VIROL. 2014;88(6):3144-60.

Merkel Cell Polyomavirus
Fischer N, Adam G
2014. Cancers in People with HIV and AIDS. Yarchoan R (Hrsg.). 1. Aufl. Springer, 113-122.

Nachweis von Bakterien, Pilzen und Viren im Hochdurchsatz
Fischer N, Grundhoff A
BIOspektrum. 2014;20(5):524-527.

Rapid Metagenomic Diagnostics for Suspected Outbreak of Severe Pneumonia
Fischer N, Rohde H, Indenbirken D, Günther T, Reumann K, Lütgehetmann M, Meyer T, Kluge S, Aepfelbacher M, Alawi M, Grundhoff A
EMERG INFECT DIS. 2014;20(6):1072-5.

Merkel cell polyomavirus detection in Merkel cell cancer tumors in Northern Germany using PCR and protein expression
Leitz M, Stieler K, Grundhoff A, Moll I, Brandner J, Fischer N
J MED VIROL. 2014;86 (10):1813-1819.

Complete Genome Sequence of Pronghorn Virus, a Pestivirus.
Neill J, Ridpath J, Fischer N, Grundhoff A, Postel A, Becher P
Genome Announc. 2014;2(3):e00575-14.

Utilization of replication-competent XMRV reporter-viruses reveals severe viral restriction in primary human cells
Stürzel C, Palesch D, Khalid M, Wissing S, Fischer N, Münch J
PLOS ONE. 2013;8(9):e74427.

In-depth investigation of archival and prospectively collected samples reveals no evidence for XMRV infection in prostate cancer.
Lee D, Jaydip D, Gaughan C, Steffen I, Tang N, Luk K, Qiu X, Urisman A, Fischer N, Molinaro R, Broz M, Schochetman G, Klein E, Ganem D, Derisi J, Simmons G, Hackett J, Silverman R, Chiu C
PLOS ONE. 2012;7(9):44954.

XMRV induces cell migration, cytokine expression and tumor angiogenesis: are 22Rv1 cells a suitable prostate cancer model?
Stieler K, Schumacher U, Horst A, Fischer N
PLOS ONE. 2012;7(7):42321.

S100A7/psoriasin expression in the human lung: unchanged in patients with COPD, but upregulated upon positive S. aureus detection.
Andresen E, Lange C, Strodthoff D, Goldmann T, Fischer N, Sahly H, Branscheid D, Heine H
BMC PULM MED. 2011;11:10.

Replication, gene expression and particle production by a consensus Merkel Cell Polyomavirus (MCPyV) genome.
Neumann F, Borchert S, Schmidt C, Reimer R, Hohenberg H, Fischer N, Grundhoff A
PLOS ONE. 2011;6(12):29112.

No detection of XMRV in blood samples and tissue sections from prostate cancer patients in Northern Europe.
Stieler K, Schindler S, Schlomm T, Hohn O, Bannert N, Simon R, Minner S, Schindler M, Fischer N
PLOS ONE. 2011;6(10):25592.

Detection of Merkel cell polyomavirus (MCPyV) in Merkel cell carcinoma cell lines: Cell morphology and growth phenotype do not reflect presence of the virus
Fischer N, Brandner J, Fuchs F, Moll I, Grundhoff A
INT J CANCER. 2010;126(9):2133-2142.

Xenotropic murine leukemia virus-related gammaretrovirus in respiratory tract.
Fischer N, Schulz C, Stieler K, Hohn O, Lange C, Drosten C, Aepfelbacher M
EMERG INFECT DIS. 2010;16(6):1000-1002.

Apobec 3G efficiently reduces infectivity of the human exogenous gammaretrovirus XMRV.
Stieler K, Fischer N
PLOS ONE. 2010;5(7):11738.

Host range and cellular tropism of the human exogenous gammaretrovirus XMRV.
Stieler K, Schulz C, Lavanya M, Aepfelbacher M, Stocking C, Fischer N
VIROLOGY. 2010;399(1):23-30.

Prevalence of human gammaretrovirus XMRV in sporadic prostate cancer.
Fischer N, Hellwinkel O, Schulz C, Chun F, Huland H, Aepfelbacher M, Schlomm T
J CLIN VIROL. 2008;43(3):277-283.

Identification of a novel Gammaretrovirus in prostate tumors of patients homozygous for R462Q RNASEL variant.
Urisman A, Molinaro R, Fischer N, Plummer S, Casey G, Klein E, Malathi K, Magi-Galluzzi C, Tubbs R, Ganem D, Silverman R, DeRisi J
PLOS PATHOG. 2006;2(3):25.

Yeast poly(A)-binding protein Pab1 shuttles between the nucleus and the cytoplasm and functions in mRNA export.
Brune C, Munchel S, Fischer N, Podtelejnikov A, Weis K
RNA. 2005;11(4):517-531.

The DEAD box protein Dhh1 stimulates the decapping enzyme Dcp1.
Fischer N, Weis K
EMBO J. 2002;21(11):2788-2797.

Functional analysis of different LMP1 proteins isolated from Epstein-Barr virus-positive carriers.
Fischer N, Kopper B, Graf N, Schlehofer J, Grässer F, Mueller-Lantzsch N
VIRUS RES. 1999;60(1):41-54.

A potential NES of the Epstein-Barr virus nuclear antigen 1 (EBNA1) does not confer shuttling.
Fischer N, Voss M, Mueller-Lantzsch N, Grässer F
FEBS LETT. 1999;447(2-3):311-314.

Isolation and analysis of two strongly transforming isoforms of the Epstein-Barr-Virus(EBV)-encoded latent membrane protein-1 (LMP1) from a single Hodgkin's lymphoma.
Mehl A, Fischer N, Rowe M, Hartmann F, Daus H, Trümper L, Pfreundschuh M, Müller-Lantzsch N, Grässer F
INT J CANCER. 1998;76(2):194-200.

Epstein-Barr virus nuclear antigen 1 forms a complex with the nuclear transporter karyopherin alpha2.
Fischer N, Kremmer E, Lautscham G, Mueller-Lantzsch N, Grässer F
J BIOL CHEM. 1997;272(7):3999-4005.

Letzte Aktualisierung aus dem FIS: 01.12.2024 - 23:37 Uhr